Chlorpropamide-alcohol flushing and diabetes
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چکیده
منابع مشابه
The chlorpropamide alcohol flush.
Many non-insulin dependent diabetics (NIDDs) on the sulphonylurea chlorpropamide experience intense facial flushing after taking alcohol even in small amounts. This chlorpropamide alcohol flush (CPAF) was first recognized within months of the introduction of the drug in the 1950s [ l ] but, although an alcohol flush occasionally occurs with tolbutamide [ 2 , 31, it has not been reported with ot...
متن کاملEpidemiological study of prevalence of chlorpropamide alcohol flushing in insulin dependent diabetics, non-insulin dependent diabetics, and non-diabetics.
An epidemiological study was carried out to compare the prevalence of facial flushing in non-diabetics, patients with insulin dependent diabetes, and patients with non-insulin dependent diabetes in response to 40 ml sherry taken 12 hours after 250 mg chlorpropamide or placebo, administered double blind in randomised order. A flush after chlorpropamide but not placebo was reported by 6.2% of non...
متن کاملBronchoconstriction in response to ipratropium bromide.
Pyke DA, Leslie RDG. Chlorpropamide-alcohol flushing: a definition of its relation to non-insulin-dependent diabetes. Br Med J 1978;ii: 1521-2. 2 Barnett AH, Pyke DA. Chlorpropamide-alcohol flushing and large-vessel disease in non-insulin-dependent diabetes. Br MedJ7 1980;281:261-2. 3 Jerntorp P, Almer L-O. Chlorpropamide-alcohol flushing in relation to macroangiopathy and peripheral neuropathy...
متن کاملChlorpropamide alcohol flush and circulating met-enkephalin: a positive link.
Chlorpropamide-alcohol flushing may be due to sensitivity to endogenous opiates. To investigate this possibility the plasma met-enkephalin and beta-endorphin responses to sherry with and without chlorpropamide were studied in six patients with non-insulin dependent diabetes and in six normal subjects. After chlorpropamide all patients showed a rise in met-enkephalin concentrations from a basal ...
متن کاملBlood concentrations of acetaldehyde during chlorpropamide-alcohol flush.
To test the suggestion that chlorpropamide-alcohol flushing (CPAF) resembles the disulfiram effect and might be mediated by acetaldehyde, the initial metabolite of alcohol, blood concentrations of acetaldehyde were measured after a drink of alcohol in controls and diabetics positive and negative for CPAF. The CPAF-positive diabetics had significantly greater blood acetaldehyde concentrations af...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1981
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00252693